Store-dependent and -independent Modes Regulating Ca(2+) Release-activated Ca(2+) Channel Activity of Human Orai1 and Orai3

We evaluated currents induced by expression of human homologs of Orai together with STIM1 in human embryonic kidney cells. When co-expressed with STIM1, Orai1 induced a large inwardly rectifying Ca(2+)-selective current with Ca(2+)-induced slow inactivation. A point mutation of Orai1 (E106D) altered...

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Bibliographic Details
Main Authors: Zhang, Shenyuan L., Kozak, J. Ashot, Jiang, Weihua, Yeromin, Andriy V., Chen, Jing, Yu, Ying, Penna, Aubin, Shen, Wei, Chi, Victor, Cahalan, Michael D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427323/
https://ncbi.nlm.nih.gov/pubmed/18420579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801536200
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