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Loss of cortical actin filaments in insulin-resistant skeletal muscle cells impairs GLUT4 vesicle trafficking and glucose transport

Study has demonstrated an essential role of cortical filamentous actin (F-actin) in insulin-regulated glucose uptake by skeletal muscle. Here, we tested whether perturbations in F-actin contributed to impaired insulin responsiveness provoked by hyperinsulinemia. In L6 myo-tubes stably expressing GLU...

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書誌詳細
主要な著者: McCarthy, Alicia M., Spisak, Kristen O., Brozinick, Joseph T., Elmendorf, Jeffrey S.
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424226/
https://ncbi.nlm.nih.gov/pubmed/16774991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00107.2006
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