Wird geladen...

Degradation of fibrillar forms of Alzheimer’s amyloid β-peptide by macrophages

Cultured microglia internalize fibrillar amyloid Aβ (fAβ) and deliver it to lysosomes. Degradation of fAβ by microglia is incomplete, but macrophages degrade fAβ efficiently. When mannose-6 phosphorylated lysosomal enzymes were added to the culture medium of microglia, degradation of fAβ was increas...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Majumdar, Amitabha, Chung, Haeyong, Dolios, Georgia, Wang, Rong, Asamoah, Nikiya, Lobel, Peter, Maxfield, Frederick R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424018/
https://ncbi.nlm.nih.gov/pubmed/17222479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.12.001
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!