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ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O(6)-Methylguanine Adducts
S(N)1-type alkylating agents that produce cytotoxic O(6)-methyl-G (O(6)-meG) DNA adducts induce cell cycle arrest and apoptosis in a manner requiring the DNA mismatch repair (MMR) proteins MutSα and MutLα. Here, we show that checkpoint signaling in response to DNA methylation occurs during S phase a...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2423943/ https://ncbi.nlm.nih.gov/pubmed/16713580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.04.023 |
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