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Hypoxic Inhibition of Nonsense-Mediated RNA Decay Regulates Gene Expression and the Integrated Stress Response
Nonsense-mediated RNA decay (NMD) rapidly degrades both mutated mRNAs and nonmutated cellular mRNAs in what is thought to be a constitutive fashion. Here we demonstrate that NMD is inhibited in hypoxic cells and that this inhibition is dependent on phosphorylation of the α subunit of eukaryotic init...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2423288/ https://ncbi.nlm.nih.gov/pubmed/18362164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02284-07 |
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