Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

PDK1 activates a group of kinases, including protein kinase B (PKB)/Akt, p70 ribosomal S6 kinase (S6K), and serum and glucocorticoid-induced protein kinase (SGK), that mediate many of the effects of insulin as well as other agonists. PDK1 interacts with phosphoinositides through a pleckstrin homolog...

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Egile Nagusiak: Bayascas, Jose R., Wullschleger, Stephan, Sakamoto, Kei, García-Martínez, Juan M., Clacher, Carol, Komander, David, van Aalten, Daan M. F., Boini, Krishna M., Lang, Florian, Lipina, Christopher, Logie, Lisa, Sutherland, Calum, Chudek, John A., van Diepen, Janna A., Voshol, Peter J., Lucocq, John M., Alessi, Dario R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2008
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423167/
https://ncbi.nlm.nih.gov/pubmed/18347057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02032-07
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