Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

PDK1 activates a group of kinases, including protein kinase B (PKB)/Akt, p70 ribosomal S6 kinase (S6K), and serum and glucocorticoid-induced protein kinase (SGK), that mediate many of the effects of insulin as well as other agonists. PDK1 interacts with phosphoinositides through a pleckstrin homolog...

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Main Authors: Bayascas, Jose R., Wullschleger, Stephan, Sakamoto, Kei, García-Martínez, Juan M., Clacher, Carol, Komander, David, van Aalten, Daan M. F., Boini, Krishna M., Lang, Florian, Lipina, Christopher, Logie, Lisa, Sutherland, Calum, Chudek, John A., van Diepen, Janna A., Voshol, Peter J., Lucocq, John M., Alessi, Dario R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423167/
https://ncbi.nlm.nih.gov/pubmed/18347057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02032-07
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