PTEN Represses RNA Polymerase III-Dependent Transcription by Targeting the TFIIIB Complex

PTEN, a tumor suppressor whose function is frequently lost in human cancers, possesses a lipid phosphatase activity that represses phosphatidylinositol 3-kinase (PI3K) signaling, controlling cell growth, proliferation, and survival. The potential for PTEN to regulate the synthesis of RNA polymerase...

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Bibliographic Details
Main Authors: Woiwode, Annette, Johnson, Sandra A. S., Zhong, Shuping, Zhang, Cheng, Roeder, Robert G., Teichmann, Martin, Johnson, Deborah L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423115/
https://ncbi.nlm.nih.gov/pubmed/18391023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01912-07
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