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p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB
The tumor suppressor p53 is a transcription factor that controls cellular growth and proliferation. p53 targets include RNA polymerase (pol) III-dependent genes encoding untranslated RNAs such as tRNA and 5S rRNA. These genes are repressed through interaction of p53 with TFIIIB, a TATA-binding prote...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC156762/ https://ncbi.nlm.nih.gov/pubmed/12773395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg265 |
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