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p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB

The tumor suppressor p53 is a transcription factor that controls cellular growth and proliferation. p53 targets include RNA polymerase (pol) III-dependent genes encoding untranslated RNAs such as tRNA and 5S rRNA. These genes are repressed through interaction of p53 with TFIIIB, a TATA-binding prote...

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Published in:EMBO J
Main Authors: Crighton, Diane, Woiwode, Annette, Zhang, Cheng, Mandavia, Nihar, Morton, Jennifer P., Warnock, Lorna J., Milner, Jo, White, Robert J., Johnson, Deborah L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2003
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156762/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12773395/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg265
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