Spatially-Directed Assembly of a Heterotetrameric Cre-Lox Synapse Restricts Recombination Specificity

The pseudo-fourfold homo-tetrameric synapse formed by Cre protein and target DNA restricts site-specific recombination to sequences containing dyad-symmetric Cre-binding repeats. Mixtures of engineered altered-specificity Cre monomers can form heterotetramers that recombine non-identical asymmetric...

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Hlavní autoři: Gelato, Kathy A., Martin, Shelly S., Liu, Patty H., Saunders, April A., Baldwin, Enoch P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2418607/
https://ncbi.nlm.nih.gov/pubmed/18374357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.02.058
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