A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is an inherited muscle-wasting disease caused by the absence of a muscle cytoskeletal protein, dystrophin. We have previously shown that utrophin, the autosomal homologue of dystrophin, is able to compensate for the absence of dystrophin in a mouse model of DMD; we...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Burton, Edward A., Tinsley, Jonathon M., Holzfeind, Paul J., Rodrigues, Nanda R., Davies, Kay E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1999
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC24184/
https://ncbi.nlm.nih.gov/pubmed/10570192
Tagiau: Ychwanegu Tag
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