A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is an inherited muscle-wasting disease caused by the absence of a muscle cytoskeletal protein, dystrophin. We have previously shown that utrophin, the autosomal homologue of dystrophin, is able to compensate for the absence of dystrophin in a mouse model of DMD; we...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Burton, Edward A., Tinsley, Jonathon M., Holzfeind, Paul J., Rodrigues, Nanda R., Davies, Kay E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24184/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570192/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.14025
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