Deletion of Hexose-6-phosphate Dehydrogenase Activates the Unfolded Protein Response Pathway and Induces Skeletal Myopathy

Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes. In liver H6PD is required for the 11-oxoreductase activity of 11β-hydroxysteroid dehydrogenase type 1, which converts inactive 11...

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Bibliografische gegevens
Hoofdauteurs: Lavery, Gareth G., Walker, Elizabeth A., Turan, Nil, Rogoff, Daniela, Ryder, Jeffery W., Shelton, John M., Richardson, James A., Falciani, Francesco, White, Perrin C., Stewart, Paul M., Parker, Keith L., McMillan, Daniel R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
Onderwerpen:
Molecular Basis of Cell and Developmental Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2417187/
https://ncbi.nlm.nih.gov/pubmed/18222920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710067200
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