Deletion of Hexose-6-phosphate Dehydrogenase Activates the Unfolded Protein Response Pathway and Induces Skeletal Myopathy

Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes. In liver H6PD is required for the 11-oxoreductase activity of 11β-hydroxysteroid dehydrogenase type 1, which converts inactive 11...

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Detalhes bibliográficos
Main Authors: Lavery, Gareth G., Walker, Elizabeth A., Turan, Nil, Rogoff, Daniela, Ryder, Jeffery W., Shelton, John M., Richardson, James A., Falciani, Francesco, White, Perrin C., Stewart, Paul M., Parker, Keith L., McMillan, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2417187/
https://ncbi.nlm.nih.gov/pubmed/18222920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710067200
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