Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Stavudine Analogue, 4′-Ethynyl Stavudine Triphosphate

2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T), a recently discovered nucleoside reverse transcriptase (RT) inhibitor, exhibits 5- to 10-fold-higher activity against human immunodeficiency virus type 1 (HIV-1) and less cytotoxicity than does its parental compound d4T (stavudine). Using stead...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Guangwei, Wang, Jimin, Cheng, Yao, Dutschman, Ginger E., Tanaka, Hiromichi, Baba, Masanori, Cheng, Yung-Chi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415781/
https://ncbi.nlm.nih.gov/pubmed/18391035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00083-08
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