Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

BACKGROUND: Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD(50 )of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Yue-Jin, Lundy, Paul M, Lazaris, Anthoula, Huang, Yue, Baldassarre, Hernan, Wang, Bin, Turcotte, Carl, Côté, Mélanie, Bellemare, Annie, Bilodeau, Annie S, Brouillard, Sandra, Touati, Madjid, Herskovits, Peter, Bégin, Isabelle, Neveu, Nathalie, Brochu, Eric, Pierson, Janice, Hockley, Duncan K, Cerasoli, Douglas M, Lenz, David E, Wilgus, Harvey, Karatzas, Costas N, Langermann, Solomon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2008
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415180/
https://ncbi.nlm.nih.gov/pubmed/18485214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-50
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