Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

BACKGROUND: Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD(50 )of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum...

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Detalhes bibliográficos
Main Authors: Huang, Yue-Jin, Lundy, Paul M, Lazaris, Anthoula, Huang, Yue, Baldassarre, Hernan, Wang, Bin, Turcotte, Carl, Côté, Mélanie, Bellemare, Annie, Bilodeau, Annie S, Brouillard, Sandra, Touati, Madjid, Herskovits, Peter, Bégin, Isabelle, Neveu, Nathalie, Brochu, Eric, Pierson, Janice, Hockley, Duncan K, Cerasoli, Douglas M, Lenz, David E, Wilgus, Harvey, Karatzas, Costas N, Langermann, Solomon
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415180/
https://ncbi.nlm.nih.gov/pubmed/18485214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-50
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