The Butyrylcholinesterase K Variant Confers Structurally Derived Risks for Alzheimer Pathology(♦)

The K variant of butyrylcholinesterase (BChE-K, 20% incidence) is a long debated risk factor for Alzheimer disease (AD). The A539T substitution in BChE-K is located at the C terminus, which is essential both for BChE tetramerization and for its capacity to attenuate β-amyloid (Aβ) fibril formation....

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Detalhes bibliográficos
Main Authors: Podoly, Erez, Shalev, Deborah E., Shenhar-Tsarfaty, Shani, Bennett, Estelle R., Ben Assayag, Einor, Wilgus, Harvey, Livnah, Oded, Soreq, Hermona
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Genomics, Proteomics, and Bioinformatics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719355/
https://ncbi.nlm.nih.gov/pubmed/19383604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.004952
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