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The Butyrylcholinesterase K Variant Confers Structurally Derived Risks for Alzheimer Pathology(♦)
The K variant of butyrylcholinesterase (BChE-K, 20% incidence) is a long debated risk factor for Alzheimer disease (AD). The A539T substitution in BChE-K is located at the C terminus, which is essential both for BChE tetramerization and for its capacity to attenuate β-amyloid (Aβ) fibril formation....
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719355/ https://ncbi.nlm.nih.gov/pubmed/19383604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.004952 |
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