Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

BACKGROUND: Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD(50 )of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum...

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Detaylı Bibliyografya
Asıl Yazarlar: Huang, Yue-Jin, Lundy, Paul M, Lazaris, Anthoula, Huang, Yue, Baldassarre, Hernan, Wang, Bin, Turcotte, Carl, Côté, Mélanie, Bellemare, Annie, Bilodeau, Annie S, Brouillard, Sandra, Touati, Madjid, Herskovits, Peter, Bégin, Isabelle, Neveu, Nathalie, Brochu, Eric, Pierson, Janice, Hockley, Duncan K, Cerasoli, Douglas M, Lenz, David E, Wilgus, Harvey, Karatzas, Costas N, Langermann, Solomon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415180/
https://ncbi.nlm.nih.gov/pubmed/18485214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-50
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