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Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6

Low density lipoprotein receptor-related protein 6 (LRP6) and its homologue LRP5 serve as Wnt co-receptors that are essential for the Wnt/β-catenin pathway. Wnt activation of LRP6 leads to recruitment of the scaffolding protein Axin and inhibition of Axin-mediated phosphorylation/destruction of β-ca...

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מידע ביבליוגרפי
Main Authors: MacDonald, Bryan T., Yokota, Chika, Tamai, Keiko, Zeng, Xin, He, Xi
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2414294/
https://ncbi.nlm.nih.gov/pubmed/18362152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800327200
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