Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma

BACKGROUND: CTLA4-blocking antibodies induce tumor regression in a subset of patients with melanoma. Analysis of immune parameters in peripheral blood may help define how responses are mediated. METHODS: Peripheral blood from HLA-A*0201-positive patients with advanced melanoma receiving tremelimumab...

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Autori principali: Comin-Anduix, Begoña, Lee, Yohan, Jalil, Jason, Algazi, Alain, de la Rocha, Pilar, Camacho, Luis H, Bozon, Viviana A, Bulanhagui, Cecile A, Seja, Elisabeth, Villanueva, Arturo, Straatsma, Bradley R, Gualberto, Antonio, Economou, James S, Glaspy, John A, Gomez-Navarro, Jesus, Ribas, Antoni
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2412852/
https://ncbi.nlm.nih.gov/pubmed/18452610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-6-22
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