Inactivation of class II transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-γ in haematopoietic tumour cells

By presenting immunogenic peptides at the cell surface, major histocompatibility complex (MHC) class II molecules play a key role in the control of adaptive immune responses. Whether expressed constitutively or induced by interferon-γ, expression of MHC class II molecules is regulated via coactivato...

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Autori principali: Morimoto, Y, Toyota, M, Satoh, A, Murai, M, Mita, H, Suzuki, H, Takamura, Y, Ikeda, H, Ishida, T, Sato, N, Tokino, T, Imai, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2004
Soggetti:
Molecular and Cellular Pathology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410180/
https://ncbi.nlm.nih.gov/pubmed/14970863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601602
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