Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours

Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to bet...

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Detalhes bibliográficos
Main Authors: Murai, M, Toyota, M, Satoh, A, Suzuki, H, Akino, K, Mita, H, Sasaki, Y, Ishida, T, Shen, L, Garcia-Manero, G, Issa, J-P J, Hinoda, Y, Tokino, T, Imai, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361956/
https://ncbi.nlm.nih.gov/pubmed/15756280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602422
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