Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer

Gastric cancer cells often show altered Ras signaling, though the underlying molecular mechanism is not fully understood. We examined the expression profile of eight ras-association domain family (RASSF) genes plus MST1/2 and found that RASSF2A is the most frequently downregulated in gastric cancer....

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Autores principales: Maruyama, Reo, Akino, Kimishige, Toyota, Minoru, Suzuki, Hiromu, Imai, Takashi, Ohe-Toyota, Mutsumi, Yamamoto, Eiichiro, Nojima, Masanori, Fujikane, Tomoko, Sasaki, Yasushi, Yamashita, Toshiharu, Watanabe, Yoshiyuki, Hiratsuka, Hiroyoshi, Hirata, Koichi, Itoh, Fumio, Imai, Kohzoh, Shinomura, Yasuhisa, Tokino, Takashi
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2008
Materias:
Cancer Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2500213/
https://ncbi.nlm.nih.gov/pubmed/18310659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn060
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