A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer

The purpose of this phase II trial was to compare the efficacy, safety and pharmacokinetics of four irinotecan schedules for the treatment of metastatic colorectal cancer. In total, 174 5-fluorouracil pretreated patients were randomised to: arm A (n=41), 350 mg m(−2) irinotecan as a 90-min i.v. infu...

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主要な著者: Schoemaker, N E, Kuppens, I E L M, Moiseyenko, V, Glimelius, B, Kjaer, M, Starkhammer, H, Richel, D J, Smaaland, R, Bertelsen, K, Poulsen, J P, Voznyi, E, Norum, J, Fennelly, D, Tveit, K M, Garin, A, Gruia, G, Mourier, A, Sibaud, D, Lefebvre, P, Beijnen, J H, Schellens, J H M, ten Bokkel Huinink, W W
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2004
主題:
Clinical
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409929/
https://ncbi.nlm.nih.gov/pubmed/15381932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602172
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