A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

Polymeric drug conjugates are a new and experimental class of drug delivery systems with pharmacokinetic promises. The antineoplastic drug camptothecin was linked to a water-soluble polymeric backbone (MAG-CPT) and administrated as a 30 min infusion over 3 consecutive days every 4 weeks to patients...

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Main Authors: Schoemaker, N E, van Kesteren, C, Rosing, H, Jansen, S, Swart, M, Lieverst, J, Fraier, D, Breda, M, Pellizzoni, C, Spinelli, R, Porro, M Grazia, Beijnen, J H, Schellens, J H M, ten Bokkel Huinink, WW
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2002
Assuntos:
Clinical
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364251/
https://ncbi.nlm.nih.gov/pubmed/12237769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600516
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