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Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level

Small peptides that perturb intracellular signalling pathways are useful tools in the identification and validation of new drug targets. To facilitate the analysis of biologically active peptides, we have developed retroviral vectors expressing an intracellular scaffold protein that significantly en...

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Bibliografski detalji
Glavni autori: Karlsson, G B, Jensen, A, Stevenson, L F, Woods, Y L, Lane, D P, Sørensen, M S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409917/
https://ncbi.nlm.nih.gov/pubmed/15381928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602143
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