Structural Basis for Inhibition of the MDM2:p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display

The oncoprotein MDM2 binds to tumor suppressor protein p53 and inhibits its anticancer activity, which leads to promotion of tumor cell growth and tumor survival. Abrogation of the p53:MDM2 interaction reportedly results in reactivation of the p53 pathway and inhibition of tumor cell proliferation....

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Main Authors: Nagata, Takashi, Shirakawa, Kie, Kobayashi, Naohiro, Shiheido, Hirokazu, Tabata, Noriko, Sakuma-Yonemura, Yuko, Horisawa, Kenichi, Katahira, Masato, Doi, Nobuhide, Yanagawa, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183577/
https://ncbi.nlm.nih.gov/pubmed/25275651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109163
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