Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP. A decreased neutralising antibody formation was observed, offering possibilities fo...

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Bibliographic Details
Main Authors: van Etten, B, Eggermont, A M M, Ambagtsheer, G, van Tiel, S T, ten Hagen, T L M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2004
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409916/
https://ncbi.nlm.nih.gov/pubmed/15480435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602151
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