T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

Regulatory T (Treg) cells safeguard against autoimmunity and immune pathology. Because determinants of the Treg cell fate are not completely understood, we have delineated signaling events that control the de novo expression of Foxp3 in naive peripheral CD4 T cells and in thymocytes. We report that...

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Bibliografski detalji
Glavni autori: Sauer, Stephan, Bruno, Ludovica, Hertweck, Arnulf, Finlay, David, Leleu, Marion, Spivakov, Mikhail, Knight, Zachary A., Cobb, Bradley S., Cantrell, Doreen, O'Connor, Eric, Shokat, Kevan M., Fisher, Amanda G., Merkenschlager, Matthias
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409380/
https://ncbi.nlm.nih.gov/pubmed/18509048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800928105
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