T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

Regulatory T (Treg) cells safeguard against autoimmunity and immune pathology. Because determinants of the Treg cell fate are not completely understood, we have delineated signaling events that control the de novo expression of Foxp3 in naive peripheral CD4 T cells and in thymocytes. We report that...

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Detalhes bibliográficos
Main Authors: Sauer, Stephan, Bruno, Ludovica, Hertweck, Arnulf, Finlay, David, Leleu, Marion, Spivakov, Mikhail, Knight, Zachary A., Cobb, Bradley S., Cantrell, Doreen, O'Connor, Eric, Shokat, Kevan M., Fisher, Amanda G., Merkenschlager, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409380/
https://ncbi.nlm.nih.gov/pubmed/18509048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800928105
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