A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.

We have shown that a drug-resistant mutant from a clinical isolate of herpes simplex virus contains a single point mutation in the DNA polymerase gene that confers resistance to both acyclovir and foscarnet. The mutated amino acid is located within a distinct conserved region shared among alpha-like...

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Bibliografische gegevens

Gepubliceerd in:	J Virol
Hoofdauteurs:	Hwang, C B, Ruffner, K L, Coen, D M
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1992
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1310779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.3.1774-1776.1992
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