A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.

We have shown that a drug-resistant mutant from a clinical isolate of herpes simplex virus contains a single point mutation in the DNA polymerase gene that confers resistance to both acyclovir and foscarnet. The mutated amino acid is located within a distinct conserved region shared among alpha-like...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Hwang, C B, Ruffner, K L, Coen, D M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1310779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.3.1774-1776.1992
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!