An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

The muscle-specific microRNAs, miR-1 and miR-133, play important roles in muscle growth and differentiation. Here, we show that the MEF2 transcription factor, an essential regulator of muscle development, directly activates transcription of a bicistronic primary transcript encoding miR-1-2 and 133a-...

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Bibliographic Details
Main Authors: Liu, Ning, Williams, Andrew H., Kim, Yuri, McAnally, John, Bezprozvannaya, Svetlana, Sutherland, Lillian B., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409229/
https://ncbi.nlm.nih.gov/pubmed/18093911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710558105
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