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A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced protein synthesis, assembly of sarcomeres, and reactivation of fetal genes, often culminating in heart failure and sudden death. Given the e...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: van Rooij, Eva, Sutherland, Lillian B., Liu, Ning, Williams, Andrew H., McAnally, John, Gerard, Robert D., Richardson, James A., Olson, Eric N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838739/
https://ncbi.nlm.nih.gov/pubmed/17108080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608791103
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