Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons

Tetanus neurotoxin causes the spastic paralysis of tetanus by blocking neurotransmitter release at inhibitory synapses of the spinal cord. This is due to the penetration of the toxin inside the neuronal cytosol where it cleaves specifically VAMP/synaptobrevin, an essential component of the neuroexoc...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Matteoli, Michela, Verderio, Claudia, Rossetto, Ornella, Iezzi, Numa, Coco, Silvia, Schiavo, Giampietro, Montecucco, Cesare
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1996
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24089/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8917587/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.23.13310
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