Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status

p53 tumour-suppressor gene is involved in cell growth control, arrest and apoptosis. Nevertheless cell cycle arrest and apoptosis induction can be observed in p53-defective cells after exposure to DNA-damaging agents such as 5-fluorouracil (5-FU) suggesting the importance of alternative pathways via...

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Detalhes bibliográficos
Main Authors: Mirjolet, J-F, Barberi-Heyob, M, Didelot, C, Peyrat, J-P, Abecassis, J, Millon, R, Merlin, J-L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408783/
https://ncbi.nlm.nih.gov/pubmed/11044365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1455
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