Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.

Six human cancer cell lines exhibiting a large range of sensitivity to 5-fluorouracil (5-FU) were evaluated for thymidylate synthase (TS) and p53 gene expression, TS and dihydropyrimidine dehydrogenase (DPD) activity, as well as cell cycle parameters, S-phase fraction (SPF), bromodeoxyuridine labell...

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Main Authors: Mirjolet, J. F., Barberi-Heyob, M., Merlin, J. L., Marchal, S., Etienne, M. C., Milano, G., Bey, P.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group|1 1998
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2062951/
https://ncbi.nlm.nih.gov/pubmed/9662252
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