Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity

The relationship of thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on 5-fluorouracil (FU) sensitivity was tested on 19 human cancer cell lines (head and neck, breast, digestive tract) in the absence and presence of folinic acid (FA) supplementation. Thym...

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Detalhes bibliográficos
Main Authors: Etienne, M-C, Ilc, K, Formento, J-L, Laurent-Puig, P, Formento, P, Cheradame, S, Fischel, J-L, Milano, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409555/
https://ncbi.nlm.nih.gov/pubmed/14735204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601523
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