H-Ras Increases Urokinase Expression and Cell Invasion in Genetically Modified Human Astrocytes Through Ras/Raf/MEK Signaling Pathway

Previous study reported that the activation of Ras pathway cooperated with E6/E7-mediated inactivation of p53/pRb to transform immortalized normal human astrocytes (NHA/hTERT) into intracranial tumors strongly resembling human astrocytomas. The mechanism of how H-Ras contributes to astrocytoma forma...

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Autores principales: ZHAO, YUNGE, XIAO, AIZHEN, DIPIERRO, CHARLES G., ABDEL-FATTAH, RANA, AMOS, SAMSON, REDPATH, GERARD T., CARPENTER, JOAN E., PIEPER, RUSSELL O., HUSSAINI, ISA M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408768/
https://ncbi.nlm.nih.gov/pubmed/18383343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20667
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