Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes

BACKGROUND: Chromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occasional chromosome missegregations during cell division. Two of the causes of CIN are weakened mitotic checkpoint signaling and persistent merotelic attachments that result in lagging chrom...

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Detalhes bibliográficos
Main Authors: Jelluma, Nannette, Brenkman, Arjan B., McLeod, Ian, Yates, John R., Cleveland, Don W., Medema, René H., Kops, Geert J. P. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408436/
https://ncbi.nlm.nih.gov/pubmed/18545697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002415
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