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Insulin-Like Growth Factor-II Is Increased in Systemic Sclerosis-Associated Pulmonary Fibrosis and Contributes to the Fibrotic Process via Jun N-Terminal Kinase- and Phosphatidylinositol-3 Kinase-Dependent Pathways

Systemic sclerosis (SSc)-related pulmonary fibrosis, for which there are few effective therapies, is the most common cause of SSc-related mortality. We examined insulin-like growth factor (IGF)-II expression in explanted lung tissues from control and SSc patients to determine its role in the pathoge...

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Hlavní autoři: Hsu, Eileen, Feghali-Bostwick, Carol A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408418/
https://ncbi.nlm.nih.gov/pubmed/18467708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071021
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