Overexpression of Lymphotoxin in T Cells Induces Fulminant Thymic Involution

Activated lymphocytes and lymphoid-tissue inducer cells express lymphotoxins (LTs), which are essential for the organogenesis and maintenance of lymphoreticular microenvironments. Here we describe that T-cell-restricted overexpression of LT induces fulminant thymic involution. This phenotype was pre...

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Autors principals: Heikenwalder, Mathias, Prinz, Marco, Zeller, Nicolas, Lang, Karl S., Junt, Tobias, Rossi, Simona, Tumanov, Alexei, Schmidt, Hauke, Priller, Josef, Rülicke, Thomas, Macpherson, Andrew J., Holländer, Georg A., Nedospasov, Sergei A., Aguzzi, Adriano
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2008
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408416/
https://ncbi.nlm.nih.gov/pubmed/18483211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070572
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