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A lymphotoxin-driven pathway to hepatocellular carcinoma
Hepatitis B and C viruses (HBV, HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) α, β and their receptor (LTβR) are upregulated in HBV- or HCV-induced hepatitis and HCC. Liver-specific LTαβ expression in mice ind...
Gespeichert in:
Veröffentlicht in: | Cancer Cell |
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Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
2009
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4422166/ https://ncbi.nlm.nih.gov/pubmed/19800575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.08.021 |
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