A lymphotoxin-driven pathway to hepatocellular carcinoma

Hepatitis B and C viruses (HBV, HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) α, β and their receptor (LTβR) are upregulated in HBV- or HCV-induced hepatitis and HCC. Liver-specific LTαβ expression in mice ind...

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Publicado no:Cancer Cell
Main Authors: Haybaeck, Johannes, Zeller, Nicolas, Wolf, Monika Julia, Weber, Achim, Wagner, Ulrich, do Kurrer, Michael O, Bremer, Juliane, Iezzi, Giandomenica, Graf, Rolf, Clavien, Pierre-Alain, Thimme, Robert, Blum, Hubert, Nedospasov, Sergei A., Zatloukal, Kurt, Ramzan, Muhammad, Ciesek, Sandra, Pietschmann, Thomas, Marche, Patrice N., Karin, Michael, Kopf, Manfred, Browning, Jeffrey L., Aguzzi, Adriano, Heikenwalder, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422166/
https://ncbi.nlm.nih.gov/pubmed/19800575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.08.021
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