Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

Insulin-like growth factor-binding protein-3 (IGFBP-3) regulates IGF bioactivity and also independently modulates cell growth and survival. By using a yeast two-hybrid screen to identify IGFBP-3-interacting proteins, we cloned humanin (HN) as an IGFBP-3-binding partner. HN is a 24-aa peptide that ha...

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Bibliographic Details
Main Authors: Ikonen, Maaria, Liu, Bingrong, Hashimoto, Yuichi, Ma, Liqun, Lee, Kuk-Wha, Niikura, Takako, Nishimoto, Ikuo, Cohen, Pinchas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC240741/
https://ncbi.nlm.nih.gov/pubmed/14561895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2135111100
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