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Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells
p53, the most commonly mutated gene in human tumors, is believed to play a crucial role in the prevention of cancer by protecting cells from mutation, a theory commonly known as the “Guardian of the Genome” hypothesis. There are two hypotheses as to how this can occur. In the first, p53 protects the...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC240708/ https://ncbi.nlm.nih.gov/pubmed/14569010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2235595100 |
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