Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53.

We have used an in vivo tumor model to evaluate the consequences of p53 tumor suppressor protein deficiency in a tissue-specific context. By breeding MMTV-ras transgenic mice, which are highly susceptible to the development of mammary and salivary tumors, with p53(-/-) mice, we generated three class...

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Detalhes bibliográficos
Main Authors: Hundley, J E, Koester, S K, Troyer, D A, Hilsenbeck, S G, Subler, M A, Windle, J J
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC231798/
https://ncbi.nlm.nih.gov/pubmed/9001226
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