Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

The extracellular signal-regulated kinase (ERK) is a component of the mitogen-activated protein kinase cascade. Exon 2 of erk2 was deleted by homologous recombination and resulted in embryonic lethality at embryonic day 6.5. erk2 mutant embryos did not form mesoderm and showed increased apoptosis bu...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yao, Yao, Li, Wei, Wu, Junwei, Germann, Ursula A., Su, Michael S. S., Kuida, Keisuke, Boucher, Diane M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240691/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14566055/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2134254100
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