NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth

Glutamate antagonists limit the growth of human cancers in vitro. The mechanism of anticancer action of NMDA antagonists is not known, however. In this article, we report that the NMDA antagonist dizocilpine inhibits the extracellular signal-regulated kinase 1/2 pathway, an intracellular signaling c...

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Detalhes bibliográficos
Principais autores: Stepulak, Andrzej, Sifringer, Marco, Rzeski, Wojciech, Endesfelder, Stefanie, Gratopp, Alexander, Pohl, Elena E., Bittigau, Petra, Felderhoff-Mueser, Ursula, Kaindl, Angela M., Bührer, Christoph, Hansen, Henrik H., Stryjecka-Zimmer, Marta, Turski, Lechoslaw, Ikonomidou, Chrysanthy
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1266139/
https://ncbi.nlm.nih.gov/pubmed/16230611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507679102
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