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The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA

The HIV type 1 (HIV-1) Tat protein stimulates transcription elongation by recruiting P-TEFb (CDK9/cyclin T1) to the transactivation response (TAR) RNA structure. Tat-induced CDK9 kinase has been shown to phosphorylate Ser-5 of RNA polymerase II (RNAP II) C-terminal domain (CTD). Results presented he...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zhou, Meisheng, Deng, Longwen, Kashanchi, Fatah, Brady, John N., Shatkin, Aaron J., Kumar, Ajit
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240675/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14569024/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1835726100
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