The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA

The HIV type 1 (HIV-1) Tat protein stimulates transcription elongation by recruiting P-TEFb (CDK9/cyclin T1) to the transactivation response (TAR) RNA structure. Tat-induced CDK9 kinase has been shown to phosphorylate Ser-5 of RNA polymerase II (RNAP II) C-terminal domain (CTD). Results presented he...

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Detalhes bibliográficos
Main Authors: Zhou, Meisheng, Deng, Longwen, Kashanchi, Fatah, Brady, John N., Shatkin, Aaron J., Kumar, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC240675/
https://ncbi.nlm.nih.gov/pubmed/14569024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1835726100
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